Pesquisa | Biblioteca Virtual em Saúde

1.

Bacteria SAVED from Viruses.

White, Malcolm F.

Cell ; 182(1): 5-6, 2020 07 09.

Artigo em Inglês | MEDLINE | ID: mdl-32649879

2.

Antiviral type III CRISPR signalling via conjugation of ATP and SAM.

Chi, Haotian; Hoikkala, Ville; Grüschow, Sabine; Graham, Shirley; Shirran, Sally; White, Malcolm F.

Nature ; 622(7984): 826-833, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37853119

3.

Antiviral signalling by a cyclic nucleotide activated CRISPR protease.

Rouillon, Christophe; Schneberger, Niels; Chi, Haotian; Blumenstock, Katja; Da Vela, Stefano; Ackermann, Katrin; Moecking, Jonas; Peter, Martin F; Boenigk, Wolfgang; Seifert, Reinhard; Bode, Bela E; Schmid-Burgk, Jonathan L; Svergun, Dmitri; Geyer, Matthias; White, Malcolm F; Hagelueken, Gregor.

Nature ; 614(7946): 168-174, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36423657

4.

Cyclic nucleotide-induced helical structure activates a TIR immune effector.

Hogrel, Gaëlle; Guild, Abbie; Graham, Shirley; Rickman, Hannah; Grüschow, Sabine; Bertrand, Quentin; Spagnolo, Laura; White, Malcolm F.

Nature ; 608(7924): 808-812, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35948638

5.

An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity.

Athukoralage, Januka S; McMahon, Stephen A; Zhang, Changyi; Grüschow, Sabine; Graham, Shirley; Krupovic, Mart; Whitaker, Rachel J; Gloster, Tracey M; White, Malcolm F.

Nature ; 577(7791): 572-575, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31942067

6.

CRISPR antiphage defence mediated by the cyclic nucleotide-binding membrane protein Csx23.

Grüschow, Sabine; McQuarrie, Stuart; Ackermann, Katrin; McMahon, Stephen; Bode, Bela E; Gloster, Tracey M; White, Malcolm F.

Nucleic Acids Res ; 52(6): 2761-2775, 2024 Apr 12.

Artigo em Inglês | MEDLINE | ID: mdl-38471818

7.

Activation of Csm6 ribonuclease by cyclic nucleotide binding: in an emergency, twist to open.

McQuarrie, Stuart; Athukoralage, Januka S; McMahon, Stephen A; Graham, Shirley; Ackermann, Katrin; Bode, Bela E; White, Malcolm F; Gloster, Tracey M.

Nucleic Acids Res ; 51(19): 10590-10605, 2023 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-37747760

8.

Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate.

Athukoralage, Januka S; Rouillon, Christophe; Graham, Shirley; Grüschow, Sabine; White, Malcolm F.

Nature ; 562(7726): 277-280, 2018 10.

Artigo em Inglês | MEDLINE | ID: mdl-30232454

9.

Author Correction: Cyclic nucleotide-induced helical structure activates a TIR immune effector.

Hogrel, Gaëlle; Guild, Abbie; Graham, Shirley; Rickman, Hannah; Grüschow, Sabine; Bertrand, Quentin; Spagnolo, Laura; White, Malcolm F.

Nature ; 614(7946): E15, 2023 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-36631613

10.

Structure and mechanism of the type I-G CRISPR effector.

Shangguan, Qilin; Graham, Shirley; Sundaramoorthy, Ramasubramanian; White, Malcolm F.

Nucleic Acids Res ; 50(19): 11214-11228, 2022 10 28.

Artigo em Inglês | MEDLINE | ID: mdl-36305833

11.

Repurposing the atypical type I-G CRISPR system for bacterial genome engineering.

Shangguan, Qilin; White, Malcolm F.

Microbiology (Reading) ; 169(8)2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37526970

12.

Cyclic oligoadenylate signalling and regulation by ring nucleases during type III CRISPR defence.

Athukoralage, Januka S; White, Malcolm F.

RNA ; 2021 May 13.

Artigo em Inglês | MEDLINE | ID: mdl-33986148

13.

Structure of the DNA repair helicase XPD.

Liu, Huanting; Rudolf, Jana; Johnson, Kenneth A; McMahon, Stephen A; Oke, Muse; Carter, Lester; McRobbie, Anne-Marie; Brown, Sara E; Naismith, James H; White, Malcolm F.

Cell ; 133(5): 801-12, 2008 May 30.

Artigo em Inglês | MEDLINE | ID: mdl-18510925

14.

Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector.

Grüschow, Sabine; Adamson, Catherine S; White, Malcolm F.

Nucleic Acids Res ; 49(22): 13122-13134, 2021 12 16.

Artigo em Inglês | MEDLINE | ID: mdl-34871408

15.

The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence.

Zhu, Wenlong; McQuarrie, Stuart; Grüschow, Sabine; McMahon, Stephen A; Graham, Shirley; Gloster, Tracey M; White, Malcolm F.

Nucleic Acids Res ; 49(5): 2777-2789, 2021 03 18.

Artigo em Inglês | MEDLINE | ID: mdl-33590098

16.

Regulation of the RNA and DNA nuclease activities required for Pyrococcus furiosus Type III-B CRISPR-Cas immunity.

Foster, Kawanda; Grüschow, Sabine; Bailey, Scott; White, Malcolm F; Terns, Michael P.

Nucleic Acids Res ; 48(8): 4418-4434, 2020 05 07.

Artigo em Inglês | MEDLINE | ID: mdl-32198888

17.

Fuse to defuse: a self-limiting ribonuclease-ring nuclease fusion for type III CRISPR defence.

Samolygo, Aleksei; Athukoralage, Januka S; Graham, Shirley; White, Malcolm F.

Nucleic Acids Res ; 48(11): 6149-6156, 2020 06 19.

Artigo em Inglês | MEDLINE | ID: mdl-32347937

18.

Asymmetric base-pair opening drives helicase unwinding dynamics.

Colizzi, Francesco; Perez-Gonzalez, Cibran; Fritzen, Remi; Levy, Yaakov; White, Malcolm F; Penedo, J Carlos; Bussi, Giovanni.

Proc Natl Acad Sci U S A ; 116(45): 22471-22477, 2019 11 05.

Artigo em Inglês | MEDLINE | ID: mdl-31628254

19.

Structure of the CRISPR interference complex CSM reveals key similarities with cascade.

Rouillon, Christophe; Zhou, Min; Zhang, Jing; Politis, Argyris; Beilsten-Edmands, Victoria; Cannone, Giuseppe; Graham, Shirley; Robinson, Carol V; Spagnolo, Laura; White, Malcolm F.

Mol Cell ; 52(1): 124-34, 2013 Oct 10.

Artigo em Inglês | MEDLINE | ID: mdl-24119402

20.

Cyclic oligoadenylate signalling mediates Mycobacterium tuberculosis CRISPR defence.

Grüschow, Sabine; Athukoralage, Januka S; Graham, Shirley; Hoogeboom, Tess; White, Malcolm F.

Nucleic Acids Res ; 47(17): 9259-9270, 2019 09 26.

Artigo em Inglês | MEDLINE | ID: mdl-31392987

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